Compound Detail
CHEMBL213004
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Basic Information
| ChEMBL ID | CHEMBL213004 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RKKWMBWRDQJXBM-BSYVCWPDSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
372.9
MW (Da)
3.54
ALogP
5
HBA
0
HBD
41.0
PSA (Ų)
0.57
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.84
EC50 1 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL217 | Ki | 6.84 | 6.84 | 146.0 | 1 |
| D(4) dopamine receptor CHEMBL219 | Ki | 6.46 | 6.46 | 346.0 | 1 |
| D(4) dopamine receptor CHEMBL219 | EC50 | 6.34 | 6.34 | 459.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 146.0 | nM | 6.84 | Displacement of [3H]PIPAT from human recombinant D2L receptor expressed in HEK29... | 16913699 |
| D(4) dopamine receptor | Ki | = | 346.0 | nM | 6.46 | Displacement of [3H]A-369508 from human recombinant D4.4 receptor expressed in H... | 16913699 |
| D(4) dopamine receptor | EC50 | = | 459.0 | nM | 6.34 | Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR a... | 16913699 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16913699 | 10.1021/jm060279f | D(2) dopamine receptor | 3 |
| 16913699 | 10.1021/jm060279f | D(4) dopamine receptor | 3 |
| 16913699 | 10.1021/jm060279f | Dopamine receptors; D2 & D4 | 1 |
Data from ChEMBL 36 via Core Engine