Assay Detail
Binding
CHEMBL863672
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Inhibition of porcein kidney m calpain
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Kidney |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.60 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209457 | — | — | 1 | 7.68 |
| CHEMBL288365 | — | — | 1 | 7.31 |
| CHEMBL210347 | — | — | 1 | 6.92 |
| CHEMBL378215 | — | — | 1 | 6.77 |
| CHEMBL209274 | — | — | 1 | 6.77 |
| CHEMBL211200 | — | — | 1 | 6.72 |
| CHEMBL207440 | — | — | 1 | 6.72 |
| CHEMBL378465 | — | — | 1 | 6.70 |
| CHEMBL379402 | — | — | 1 | 6.62 |
| CHEMBL209286 | — | — | 1 | 6.60 |
| CHEMBL261953 | — | — | 1 | 6.47 |
| CHEMBL208986 | — | — | 1 | 5.77 |
| CHEMBL377197 | — | — | 1 | 5.72 |
| CHEMBL209736 | — | — | 1 | 5.58 |
| CHEMBL206737 | — | — | 1 | - |
| CHEMBL288882 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209457 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL288365 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL210347 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL378215 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL209274 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL211200 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL207440 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL378465 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL379402 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL209286 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL261953 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL208986 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL377197 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL209736 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL206737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL288882 | — | IC50 | - | — | - |