Assay Detail
Binding
CHEMBL863722
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Inhibition of caspase3
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 6.84 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417149 | — | — | 1 | 7.68 |
| CHEMBL438969 | — | — | 1 | 7.60 |
| CHEMBL439872 | — | — | 1 | 7.40 |
| CHEMBL203900 | — | — | 1 | 7.36 |
| CHEMBL203971 | — | — | 1 | 7.28 |
| CHEMBL377940 | — | — | 1 | 7.27 |
| CHEMBL204529 | — | — | 1 | 7.26 |
| CHEMBL382569 | — | — | 1 | 7.23 |
| CHEMBL204645 | — | — | 1 | 7.21 |
| CHEMBL381094 | — | — | 1 | 7.18 |
| CHEMBL202971 | — | — | 1 | 7.17 |
| CHEMBL380344 | — | — | 1 | 7.16 |
| CHEMBL206844 | — | — | 1 | 7.15 |
| CHEMBL205204 | — | — | 1 | 7.11 |
| CHEMBL436945 | — | — | 1 | 7.10 |
| CHEMBL382481 | — | — | 1 | 7.08 |
| CHEMBL203788 | — | — | 1 | 7.04 |
| CHEMBL206607 | — | — | 1 | 7.02 |
| CHEMBL205169 | — | — | 1 | 7.00 |
| CHEMBL206015 | — | — | 1 | 6.99 |
| CHEMBL204612 | — | — | 1 | 6.98 |
| CHEMBL383407 | — | — | 1 | 6.96 |
| CHEMBL203709 | — | — | 1 | 6.95 |
| CHEMBL203846 | — | — | 1 | 6.93 |
| CHEMBL203216 | — | — | 1 | 6.91 |
| CHEMBL382811 | — | — | 1 | 6.86 |
| CHEMBL427023 | — | — | 1 | 6.85 |
| CHEMBL204020 | — | — | 1 | 6.84 |
| CHEMBL204756 | — | — | 1 | 6.83 |
| CHEMBL206435 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417149 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL438969 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL439872 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL203900 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL203971 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL377940 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL204529 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL382569 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL204645 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL381094 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL202971 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL380344 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL206844 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL205204 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL436945 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL382481 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL203788 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL206607 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL205169 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL206015 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL204612 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL383407 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL203709 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL203846 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL203216 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL382811 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL427023 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL204020 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL204756 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL206435 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL206376 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL381591 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL206262 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL203553 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL205255 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL380416 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL425228 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL203787 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL381480 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL381777 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL206606 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL205563 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL382859 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL380874 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL383004 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL203764 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL382860 | — | IC50 | = | 544.0 | nM | 6.26 |
| CHEMBL203552 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL205083 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL204245 | — | IC50 | = | 1380.0 | nM | 5.86 |