Assay Detail
Binding
CHEMBL863731
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Inhibition of caspase8
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.93 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438969 | — | — | 1 | 6.54 |
| CHEMBL439872 | — | — | 1 | 6.37 |
| CHEMBL382481 | — | — | 1 | 6.24 |
| CHEMBL203709 | — | — | 1 | 6.08 |
| CHEMBL202971 | — | — | 1 | 5.95 |
| CHEMBL206435 | — | — | 1 | 5.72 |
| CHEMBL204245 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438969 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL439872 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL382481 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL203709 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL202971 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL206435 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL204245 | — | IC50 | = | 24700.0 | nM | 4.61 |