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Assay Detail

CHEMBL863791

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mu calpain in porcine erythrocyte
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Calpain-1 catalytic subunit (CHEMBL4062)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

A novel series of urea-based peptidomimetic calpain inhibitors.
Sanders ML, Donkor IO.
Bioorg Med Chem Lett (2006) 16 : 1965 -1968
PubMed 16412635 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.98 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL206243 1 8.00
CHEMBL378702 1 7.82
CHEMBL205436 1 6.82
CHEMBL378731 1 6.64
CHEMBL205793 1 6.40
CHEMBL381342 1 5.94
CHEMBL203232 1 5.94
CHEMBL203680 1 5.63
CHEMBL205269 1 5.18
CHEMBL205935 1 5.17
CHEMBL207647 1 5.17
CHEMBL206601 1 5.03
CHEMBL205270 1 4.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL206243 Ki = 10.0 nM 8.00
CHEMBL378702 Ki = 15.0 nM 7.82
CHEMBL205436 Ki = 150.0 nM 6.82
CHEMBL378731 Ki = 230.0 nM 6.64
CHEMBL205793 Ki = 400.0 nM 6.40
CHEMBL381342 Ki = 1150.0 nM 5.94
CHEMBL203232 Ki = 1160.0 nM 5.94
CHEMBL203680 Ki = 2350.0 nM 5.63
CHEMBL205269 Ki = 6650.0 nM 5.18
CHEMBL205935 Ki = 6820.0 nM 5.17
CHEMBL207647 Ki = 6690.0 nM 5.17
CHEMBL206601 Ki = 9270.0 nM 5.03
CHEMBL205270 Ki = 88700.0 nM 4.05