Assay Detail
Binding
CHEMBL863917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P38 alpha MAPK
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 9.01 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199680 | — | — | 1 | 10.00 |
| CHEMBL199679 | — | — | 1 | 9.85 |
| CHEMBL369989 | — | — | 1 | 9.59 |
| CHEMBL199484 | — | — | 1 | 9.52 |
| CHEMBL381632 | — | — | 1 | 9.51 |
| CHEMBL199291 | — | — | 1 | 9.42 |
| CHEMBL199701 | — | — | 1 | 9.35 |
| CHEMBL380806 | — | — | 1 | 9.29 |
| CHEMBL199625 | — | — | 1 | 9.29 |
| CHEMBL200093 | — | — | 1 | 9.21 |
| CHEMBL200047 | — | — | 1 | 9.08 |
| CHEMBL199593 | — | — | 1 | 8.94 |
| CHEMBL199565 | — | — | 1 | 8.89 |
| CHEMBL424666 | — | — | 1 | 8.85 |
| CHEMBL199707 | — | — | 1 | 8.80 |
| CHEMBL199435 | — | — | 1 | 8.73 |
| CHEMBL200018 | — | — | 1 | 8.49 |
| CHEMBL199632 | — | — | 1 | 8.17 |
| CHEMBL381201 | — | — | 1 | 8.15 |
| CHEMBL199316 | — | — | 1 | 8.09 |
| CHEMBL200534 | — | — | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199680 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL199679 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL369989 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL199484 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL381632 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL199291 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL199701 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL380806 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL199625 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL200093 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL200047 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL199593 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL199565 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL424666 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL199707 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL199435 | — | IC50 | = | 1.87 | nM | 8.73 |
| CHEMBL200018 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL199632 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL381201 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL199316 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL200534 | — | IC50 | = | 10.5 | nM | 7.98 |