Assay Detail
Functional
CHEMBL863945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF alpha release in THP1 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.87 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381632 | — | — | 1 | 9.57 |
| CHEMBL199484 | — | — | 1 | 9.38 |
| CHEMBL199625 | — | — | 1 | 9.16 |
| CHEMBL199593 | — | — | 1 | 9.13 |
| CHEMBL199435 | — | — | 1 | 9.11 |
| CHEMBL200093 | — | — | 1 | 9.09 |
| CHEMBL199701 | — | — | 1 | 9.05 |
| CHEMBL199680 | — | — | 1 | 9.00 |
| CHEMBL380806 | — | — | 1 | 9.00 |
| CHEMBL199316 | — | — | 1 | 8.89 |
| CHEMBL199291 | — | — | 1 | 8.80 |
| CHEMBL199679 | — | — | 1 | 8.77 |
| CHEMBL199707 | — | — | 1 | 8.74 |
| CHEMBL200534 | — | — | 1 | 8.66 |
| CHEMBL381201 | — | — | 1 | 8.62 |
| CHEMBL199632 | — | — | 1 | 8.59 |
| CHEMBL199565 | — | — | 1 | 8.49 |
| CHEMBL369989 | — | — | 1 | 8.48 |
| CHEMBL200047 | — | — | 1 | 8.43 |
| CHEMBL200018 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381632 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL199484 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL199625 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL199593 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL199435 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL200093 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL199701 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL199680 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL380806 | — | IC50 | = | 0.99 | nM | 9.00 |
| CHEMBL199316 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL199291 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL199679 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL199707 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL200534 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL381201 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL199632 | — | IC50 | = | 2.59 | nM | 8.59 |
| CHEMBL199565 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL369989 | — | IC50 | = | 3.32 | nM | 8.48 |
| CHEMBL200047 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL200018 | — | IC50 | = | 3.8 | nM | 8.42 |