Assay Detail
Functional
CHEMBL863987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism at muscarinic M2 receptor in isolated guinea pig urinary bladder
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent anti-muscarinic activity in a novel series of quinuclidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 8.40 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381623 | — | — | 1 | 9.30 |
| CHEMBL370232 | — | — | 1 | 9.30 |
| CHEMBL200319 | — | — | 1 | 9.10 |
| CHEMBL200693 | — | — | 1 | 9.10 |
| CHEMBL200171 | — | — | 1 | 9.10 |
| CHEMBL382213 | — | — | 1 | 8.70 |
| CHEMBL200957 | — | — | 1 | 8.50 |
| CHEMBL201933 | — | — | 1 | 8.20 |
| CHEMBL1346 | DARIFENACIN | 4.0 | 1 | 7.80 |
| CHEMBL1382 | TOLTERODINE | 4.0 | 1 | 7.80 |
| CHEMBL200210 | — | — | 1 | 7.50 |
| CHEMBL1231 | OXYBUTYNIN | 4.0 | 1 | 7.40 |
| CHEMBL372566 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381623 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL370232 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL200319 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL200693 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL200171 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL382213 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL200957 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL201933 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL1346 | DARIFENACIN | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL1382 | TOLTERODINE | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL200210 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL1231 | OXYBUTYNIN | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL372566 | — | Kd | = | 39.81 | nM | 7.40 |