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Assay Detail

CHEMBL864168

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]PSB11 from human recombinant adenosine A3 receptor expressed in CHO cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A3 (CHEMBL256)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.
Yan L, Bertarelli DC, Hayallah AM, Meyer H, Klotz KN, Müller CE.
J Med Chem (2006) 49 : 4384 -4391
PubMed 16821798 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.96 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL210585 1 5.96
CHEMBL213878 1 -
CHEMBL377106 1 -
CHEMBL208550 1 -
CHEMBL212626 1 -
CHEMBL212625 1 -
CHEMBL209366 1 -
CHEMBL377246 1 -
CHEMBL212217 1 -
CHEMBL378102 1 -
CHEMBL211521 1 -
CHEMBL209230 1 -
CHEMBL8565 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL210585 Ki = 1083.0 nM 5.96
CHEMBL213878 Ki >= 10000.0 nM -
CHEMBL377106 Ki >= 10000.0 nM -
CHEMBL208550 Ki >= 10000.0 nM -
CHEMBL212626 Ki > 10000.0 nM -
CHEMBL212625 Ki > 1000.0 nM -
CHEMBL209366 Ki >= 1000.0 nM -
CHEMBL377246 Ki > 1000.0 nM -
CHEMBL212217 Ki > 10000.0 nM -
CHEMBL378102 Ki >= 10000.0 nM -
CHEMBL211521 Ki >= 10000.0 nM -
CHEMBL209230 Ki >= 1000.0 nM -
CHEMBL8565 Ki > 10000.0 nM -