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Compound Detail

CHEMBL209366

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CCCn1c(=O)[nH]c2[nH]c(-c3ccc(S(=O)(=O)Nc4ccccc4)cc3)nc2c1=O

Basic Information

ChEMBL ID CHEMBL209366
Phase Preclinical
Structure Type MOL
InChI Key KCUXCRYAOFJTTI-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

425.5
MW (Da)
2.29
ALogP
6
HBA
3
HBD
129.7
PSA (Ų)
0.44
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H19N5O4S
MW 425.47
Aromatic Rings 4
Heavy Atoms 30
NP-Likeness -1.32

Activity Summary

Ki 3 meas. best 8.74

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 8.74 8.74 1.8 1
Adenosine receptor A2a
CHEMBL302
Ki 7.64 7.64 23.0 1
Adenosine receptor A2b
CHEMBL255
Ki 7.5 7.5 31.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16821798 10.1021/jm060277v Adenosine receptor A3 2
16821798 10.1021/jm060277v Adenosine receptor A2a 2
16821798 10.1021/jm060277v Adenosine receptor A1 2
16821798 10.1021/jm060277v Adenosine receptor A2b 1

Data from ChEMBL 36 via Core Engine