Assay Detail
Binding
CHEMBL864198
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Inhibition of human beta tryptase
35
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 8.03 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211357 | — | — | 1 | 8.82 |
| CHEMBL212774 | — | — | 1 | 8.77 |
| CHEMBL380293 | — | — | 1 | 8.77 |
| CHEMBL213928 | — | — | 1 | 8.74 |
| CHEMBL377890 | — | — | 1 | 8.74 |
| CHEMBL377656 | — | — | 1 | 8.72 |
| CHEMBL209395 | — | — | 1 | 8.72 |
| CHEMBL214136 | — | — | 1 | 8.70 |
| CHEMBL379528 | — | — | 1 | 8.68 |
| CHEMBL213951 | — | — | 1 | 8.62 |
| CHEMBL214368 | — | — | 1 | 8.55 |
| CHEMBL214367 | — | — | 1 | 8.54 |
| CHEMBL379561 | — | — | 1 | 8.52 |
| CHEMBL213780 | — | — | 1 | 8.49 |
| CHEMBL188069 | — | — | 1 | 8.46 |
| CHEMBL276908 | — | — | 1 | 8.44 |
| CHEMBL213927 | — | — | 2 | 8.43 |
| CHEMBL378244 | — | — | 1 | 8.24 |
| CHEMBL377619 | — | — | 1 | 8.09 |
| CHEMBL210129 | — | — | 1 | 8.00 |
| CHEMBL211638 | — | — | 1 | 7.96 |
| CHEMBL209604 | — | — | 1 | 7.96 |
| CHEMBL426330 | — | — | 1 | 7.92 |
| CHEMBL213779 | — | — | 1 | 7.89 |
| CHEMBL379486 | — | — | 1 | 7.80 |
| CHEMBL213778 | — | — | 1 | 7.47 |
| CHEMBL386704 | — | — | 1 | 7.43 |
| CHEMBL211585 | — | — | 1 | 7.41 |
| CHEMBL214148 | — | — | 1 | 7.22 |
| CHEMBL214149 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211357 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL380293 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL212774 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL213928 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL377890 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL377656 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL209395 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL214136 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL379528 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL213951 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL214368 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL214367 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL379561 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL213780 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL188069 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL276908 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL213927 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL213927 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL378244 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL377619 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL210129 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL209604 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL211638 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL426330 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL213779 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL379486 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL213778 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL386704 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL211585 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL214148 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL214149 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL414865 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL213554 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL378910 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL213698 | — | Ki | = | 770.0 | nM | 6.11 |