Assay Detail
Binding
CHEMBL864250
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Inhibition of TIE2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.09 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262433 | — | — | 1 | 7.72 |
| CHEMBL214258 | — | — | 1 | 7.66 |
| CHEMBL213504 | — | — | 1 | 7.55 |
| CHEMBL376951 | — | — | 1 | 6.38 |
| CHEMBL196363 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262433 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL214258 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL213504 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL376951 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL196363 | — | IC50 | = | 730.0 | nM | 6.14 |