Assay Detail
Binding
CHEMBL864253
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CKIT
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.93 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196363 | — | — | 1 | 8.22 |
| CHEMBL262433 | — | — | 1 | 8.15 |
| CHEMBL376951 | — | — | 1 | 7.96 |
| CHEMBL213504 | — | — | 1 | 7.75 |
| CHEMBL214258 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196363 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL262433 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL376951 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL213504 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL214258 | — | IC50 | = | 28.0 | nM | 7.55 |