Assay Detail

CHEMBL864261

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ADMET

Inhibition of CYP450 1A2

ChEMBL ↗

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Target

Cytochrome P450 1A2 (CHEMBL3356) ↗

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Cytochrome P450 1A2 (CHEMBL3356) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 1A2

CHEMBL3356

Anchored from Assay target.

Protein identity Cytochrome P450 1A2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytochrome P450 1A2 (CHEMBL3356) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Identification of novel pyrazole acid antagonists for the EP1 receptor.

McKeown SC, Hall A, Giblin GM, Lorthioir O, Blunt R, Lewell XQ, Wilson RJ, Brown SH, Chowdhury A, Coleman T, Watson SP, Chessell IP, Pipe A, Clayton N, Goldsmith P.
Bioorg Med Chem Lett (2006) 16 : 4767 -4771
PubMed 16843659 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.68	4.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL213221	—	—	1	4.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL213221	—	IC50	=	21000.0	nM	4.68