Assay Detail
Functional
CHEMBL864275
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Inhibition of TRAP activity in RANKL-induced osteoclastogenesis in RAW 264.7 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of novel chemical probes for the study of tanshinone binding proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.84 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215731 | — | — | 1 | 5.02 |
| CHEMBL387196 | — | — | 1 | 4.99 |
| CHEMBL386076 | — | — | 1 | 4.91 |
| CHEMBL377478 | — | — | 1 | 4.89 |
| CHEMBL375871 | — | — | 1 | 4.82 |
| CHEMBL215254 | TANSHINONE IIB | — | 1 | 4.81 |
| CHEMBL212810 | — | — | 1 | 4.78 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | 4.74 |
| CHEMBL215983 | — | — | 1 | 4.74 |
| CHEMBL215379 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215731 | — | IC50 | = | 9560.0 | nM | 5.02 |
| CHEMBL387196 | — | IC50 | = | 10240.0 | nM | 4.99 |
| CHEMBL386076 | — | IC50 | = | 12370.0 | nM | 4.91 |
| CHEMBL377478 | — | IC50 | = | 12850.0 | nM | 4.89 |
| CHEMBL375871 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL215254 | TANSHINONE IIB | IC50 | = | 15550.0 | nM | 4.81 |
| CHEMBL212810 | — | IC50 | = | 16680.0 | nM | 4.78 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | = | 18170.0 | nM | 4.74 |
| CHEMBL215983 | — | IC50 | = | 18020.0 | nM | 4.74 |
| CHEMBL215379 | — | IC50 | = | 19130.0 | nM | 4.72 |