Assay Detail
Binding
CHEMBL864422
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Inhibition of Cathepsin L
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of a potent and selective non-basic cathepsin K inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.21 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204277 | — | — | 1 | 7.89 |
| CHEMBL204276 | — | — | 1 | 7.47 |
| CHEMBL195454 | — | — | 1 | 7.33 |
| CHEMBL206024 | — | — | 1 | 7.10 |
| CHEMBL437501 | — | — | 1 | 6.58 |
| CHEMBL382038 | — | — | 1 | 6.50 |
| CHEMBL377285 | — | — | 1 | 6.47 |
| CHEMBL380425 | — | — | 1 | 6.46 |
| CHEMBL207554 | — | — | 1 | 6.33 |
| CHEMBL437694 | — | — | 1 | 6.28 |
| CHEMBL203944 | — | — | 1 | 6.25 |
| CHEMBL206913 | — | — | 1 | 6.11 |
| CHEMBL208278 | — | — | 1 | 6.09 |
| CHEMBL381758 | — | — | 1 | 6.06 |
| CHEMBL205929 | — | — | 1 | 6.05 |
| CHEMBL205504 | — | — | 1 | 6.00 |
| CHEMBL204792 | — | — | 1 | 5.83 |
| CHEMBL206912 | — | — | 1 | 5.83 |
| CHEMBL381621 | — | — | 1 | 5.83 |
| CHEMBL382576 | — | — | 1 | 5.78 |
| CHEMBL378583 | — | — | 1 | 5.73 |
| CHEMBL426493 | — | — | 1 | 5.72 |
| CHEMBL206169 | — | — | 1 | 5.71 |
| CHEMBL382820 | — | — | 1 | 5.62 |
| CHEMBL207769 | — | — | 1 | 5.55 |
| CHEMBL207891 | — | — | 1 | 5.52 |
| CHEMBL208481 | — | — | 1 | 5.52 |
| CHEMBL206166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204277 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL204276 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL195454 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL206024 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL437501 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL382038 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL377285 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL380425 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL207554 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL437694 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL203944 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL206913 | — | IC50 | = | 771.0 | nM | 6.11 |
| CHEMBL208278 | — | IC50 | = | 809.0 | nM | 6.09 |
| CHEMBL381758 | — | IC50 | = | 878.0 | nM | 6.06 |
| CHEMBL205929 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL205504 | — | IC50 | = | 1001.0 | nM | 6.00 |
| CHEMBL204792 | — | IC50 | = | 1473.0 | nM | 5.83 |
| CHEMBL206912 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL381621 | — | IC50 | = | 1475.0 | nM | 5.83 |
| CHEMBL382576 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL378583 | — | IC50 | = | 1857.0 | nM | 5.73 |
| CHEMBL426493 | — | IC50 | = | 1915.0 | nM | 5.72 |
| CHEMBL206169 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL382820 | — | IC50 | = | 2422.0 | nM | 5.62 |
| CHEMBL207769 | — | IC50 | = | 2792.0 | nM | 5.55 |
| CHEMBL207891 | — | IC50 | = | 3047.0 | nM | 5.52 |
| CHEMBL208481 | — | IC50 | = | 3002.0 | nM | 5.52 |
| CHEMBL206166 | — | IC50 | > | 10000.0 | nM | - |