Assay Detail
Binding
CHEMBL864423
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Inhibition of Cathepsin S
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of a potent and selective non-basic cathepsin K inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.53 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204276 | — | — | 1 | 7.44 |
| CHEMBL204277 | — | — | 1 | 7.27 |
| CHEMBL206024 | — | — | 1 | 7.21 |
| CHEMBL437694 | — | — | 1 | 6.82 |
| CHEMBL207554 | — | — | 1 | 6.81 |
| CHEMBL380425 | — | — | 1 | 6.76 |
| CHEMBL437501 | — | — | 1 | 6.75 |
| CHEMBL377285 | — | — | 1 | 6.73 |
| CHEMBL205504 | — | — | 1 | 6.72 |
| CHEMBL203944 | — | — | 1 | 6.71 |
| CHEMBL206913 | — | — | 1 | 6.66 |
| CHEMBL381758 | — | — | 1 | 6.62 |
| CHEMBL208481 | — | — | 1 | 6.60 |
| CHEMBL426493 | — | — | 1 | 6.59 |
| CHEMBL206912 | — | — | 1 | 6.58 |
| CHEMBL207769 | — | — | 1 | 6.56 |
| CHEMBL208278 | — | — | 1 | 6.55 |
| CHEMBL204792 | — | — | 1 | 6.52 |
| CHEMBL381621 | — | — | 1 | 6.44 |
| CHEMBL382038 | — | — | 1 | 6.36 |
| CHEMBL195454 | — | — | 1 | 6.35 |
| CHEMBL205929 | — | — | 1 | 6.35 |
| CHEMBL207891 | — | — | 1 | 6.22 |
| CHEMBL382576 | — | — | 1 | 6.21 |
| CHEMBL382820 | — | — | 1 | 6.18 |
| CHEMBL206169 | — | — | 1 | 5.88 |
| CHEMBL378583 | — | — | 1 | 5.77 |
| CHEMBL206166 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204276 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL204277 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL206024 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL437694 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL207554 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL380425 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL437501 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL377285 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL205504 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL203944 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL206913 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL381758 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL208481 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL426493 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL206912 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL207769 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL208278 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL204792 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL381621 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL382038 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL195454 | — | IC50 | = | 451.0 | nM | 6.35 |
| CHEMBL205929 | — | IC50 | = | 449.0 | nM | 6.35 |
| CHEMBL207891 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL382576 | — | IC50 | = | 614.0 | nM | 6.21 |
| CHEMBL382820 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL206169 | — | IC50 | = | 1308.0 | nM | 5.88 |
| CHEMBL378583 | — | IC50 | = | 1698.0 | nM | 5.77 |
| CHEMBL206166 | — | IC50 | = | 6183.0 | nM | 5.21 |