Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL864457

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 K103N mutant strain infected MT4 cells by MTT method
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT4
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity.
Manetti F, Esté JA, Clotet-Codina I, Armand-Ugón M, Maga G, Crespan E, Cancio R, Mugnaini C, Bernardini C, Togninelli A, Carmi C, Alongi M, Petricci E, Massa S, Corelli F, Botta M.
J Med Chem (2005) 48 : 8000 -8008
PubMed 16335924 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 33 5.96 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL129 ZIDOVUDINE 4.0 1 8.52
CHEMBL223228 EFAVIRENZ 4.0 1 7.24
CHEMBL198465 1 7.00
CHEMBL198702 1 6.16
CHEMBL196807 1 6.06
CHEMBL57 NEVIRAPINE 4.0 1 5.41
CHEMBL199234 1 5.33
CHEMBL373030 1 5.28
CHEMBL200477 1 5.00
CHEMBL439863 1 4.96
CHEMBL197125 1 4.57
CHEMBL197343 1 -
CHEMBL199164 1 -
CHEMBL198892 1 -
CHEMBL382737 1 -
CHEMBL370996 1 -
CHEMBL196965 1 -
CHEMBL410272 1 -
CHEMBL197881 1 -
CHEMBL198370 1 -
CHEMBL196756 1 -
CHEMBL199060 1 -
CHEMBL199223 1 -
CHEMBL371251 1 -
CHEMBL199113 1 -
CHEMBL198697 1 -
CHEMBL198193 1 -
CHEMBL436507 1 -
CHEMBL196811 1 -
CHEMBL197874 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL129 ZIDOVUDINE EC50 = 3.0 nM 8.52
CHEMBL223228 EFAVIRENZ EC50 = 57.0 nM 7.24
CHEMBL198465 EC50 = 100.0 nM 7.00
CHEMBL198702 EC50 = 690.0 nM 6.16
CHEMBL196807 EC50 = 870.0 nM 6.06
CHEMBL57 NEVIRAPINE EC50 = 3900.0 nM 5.41
CHEMBL199234 EC50 = 4700.0 nM 5.33
CHEMBL373030 EC50 = 5300.0 nM 5.28
CHEMBL200477 EC50 = 10000.0 nM 5.00
CHEMBL439863 EC50 = 11000.0 nM 4.96
CHEMBL197125 EC50 = 27000.0 nM 4.57
CHEMBL197881 EC50 > 61000.0 nM -
CHEMBL410272 EC50 > 62000.0 nM -
CHEMBL196965 EC50 > 65000.0 nM -
CHEMBL370996 EC50 > 58000.0 nM -
CHEMBL382737 EC50 > 1000.0 nM -
CHEMBL198892 EC50 > 3100.0 nM -
CHEMBL199164 EC50 > 55000.0 nM -
CHEMBL197343 EC50 > 58000.0 nM -
CHEMBL200626 EC50 > 55000.0 nM -
CHEMBL372381 EC50 > 60000.0 nM -
CHEMBL198704 EC50 > 59000.0 nM -
CHEMBL198370 EC50 > 65000.0 nM -
CHEMBL196756 EC50 > 8900.0 nM -
CHEMBL199060 EC50 > 41000.0 nM -
CHEMBL199223 EC50 > 48000.0 nM -
CHEMBL371251 EC50 > 2800.0 nM -
CHEMBL199113 EC50 > 53000.0 nM -
CHEMBL198697 EC50 > 50000.0 nM -
CHEMBL198193 EC50 > 53000.0 nM -
CHEMBL436507 EC50 > 59000.0 nM -
CHEMBL196811 EC50 > 64000.0 nM -
CHEMBL197874 EC50 > 60000.0 nM -