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Assay Detail

CHEMBL864467

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Binding
Inhibitory activity against dynamin1 GTPase expressed in sheep brain
ChEMBL ↗
133
Total Activities
133
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Dynamin-1 (CHEMBL4958) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins.
Hill T, Odell LR, Edwards JK, Graham ME, McGeachie AB, Rusak J, Quan A, Abagyan R, Scott JL, Robinson PJ, McCluskey A.
J Med Chem (2005) 48 : 7781 -7788
PubMed 16302817 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 133 4.99 5.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67535 — — 1 5.77
CHEMBL199469 — — 1 5.77
CHEMBL196854 — — 1 5.77
CHEMBL198466 — — 1 5.77
CHEMBL358746 — — 1 5.68
CHEMBL144589 — — 1 5.50
CHEMBL197374 — — 1 5.30
CHEMBL144842 — — 1 5.30
CHEMBL144908 — — 1 5.29
CHEMBL198705 — — 1 5.29
CHEMBL197068 — — 1 5.22
CHEMBL198573 — — 1 5.10
CHEMBL197017 — — 1 5.10
CHEMBL198915 — — 1 5.05
CHEMBL144760 — — 1 4.58
CHEMBL197388 — — 1 4.42
CHEMBL445859 — — 1 4.38
CHEMBL371526 — — 1 4.21
CHEMBL77030 TYRPHOSTIN 47 — 1 4.16
CHEMBL371102 — — 1 4.10
CHEMBL144159 — — 1 4.08
CHEMBL371303 — — 1 4.02
CHEMBL296407 — — 1 -
CHEMBL197490 — — 1 -
CHEMBL371282 — — 1 -
CHEMBL197177 — — 1 -
CHEMBL197015 — — 1 -
CHEMBL198919 — — 1 -
CHEMBL425207 — — 1 -
CHEMBL197425 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67535 — IC50 = 1700.0 nM 5.77
CHEMBL198466 — IC50 = 1700.0 nM 5.77
CHEMBL196854 — IC50 = 1700.0 nM 5.77
CHEMBL199469 — IC50 = 1700.0 nM 5.77
CHEMBL358746 — IC50 = 2100.0 nM 5.68
CHEMBL144589 — IC50 = 3200.0 nM 5.50
CHEMBL197374 — IC50 = 5000.0 nM 5.30
CHEMBL144842 — IC50 = 5000.0 nM 5.30
CHEMBL144908 — IC50 = 5100.0 nM 5.29
CHEMBL198705 — IC50 = 5100.0 nM 5.29
CHEMBL197068 — IC50 = 6000.0 nM 5.22
CHEMBL198573 — IC50 = 8000.0 nM 5.10
CHEMBL197017 — IC50 = 8000.0 nM 5.10
CHEMBL198915 — IC50 = 9000.0 nM 5.05
CHEMBL144760 — IC50 = 26000.0 nM 4.58
CHEMBL197388 — IC50 = 38000.0 nM 4.42
CHEMBL445859 — IC50 = 42000.0 nM 4.38
CHEMBL371526 — IC50 = 61000.0 nM 4.21
CHEMBL77030 TYRPHOSTIN 47 IC50 = 70000.0 nM 4.16
CHEMBL371102 — IC50 = 80000.0 nM 4.10
CHEMBL144159 — IC50 = 84000.0 nM 4.08
CHEMBL371303 — IC50 = 95000.0 nM 4.02
CHEMBL199265 — IC50 > 100000.0 nM -
CHEMBL425390 — IC50 > 100000.0 nM -
CHEMBL380566 — IC50 > 100000.0 nM -
CHEMBL200345 — IC50 > 100000.0 nM -
CHEMBL198885 — IC50 >= 100000.0 nM -
CHEMBL198627 — IC50 > 100000.0 nM -
CHEMBL427373 — IC50 > 100000.0 nM -
CHEMBL198585 — IC50 >= 100000.0 nM -
CHEMBL198838 — IC50 >= 100000.0 nM -
CHEMBL198889 — IC50 >= 100000.0 nM -
CHEMBL382758 — IC50 >= 100000.0 nM -
CHEMBL371768 — IC50 >= 100000.0 nM -
CHEMBL198626 — IC50 > 100000.0 nM -
CHEMBL198901 — IC50 > 100000.0 nM -
CHEMBL199009 — IC50 >= 100000.0 nM -
CHEMBL381439 — IC50 >= 100000.0 nM -
CHEMBL382303 — IC50 >= 100000.0 nM -
CHEMBL198751 — IC50 >= 100000.0 nM -
CHEMBL197486 — IC50 >= 100000.0 nM -
CHEMBL199184 — IC50 >= 100000.0 nM -
CHEMBL198484 — IC50 >= 100000.0 nM -
CHEMBL199010 — IC50 >= 100000.0 nM -
CHEMBL198528 — IC50 >= 100000.0 nM -
CHEMBL372329 — IC50 >= 100000.0 nM -
CHEMBL197238 — IC50 >= 100000.0 nM -
CHEMBL198683 — IC50 >= 100000.0 nM -
CHEMBL371093 — IC50 >= 100000.0 nM -
CHEMBL370851 — IC50 > 100000.0 nM -