Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL864488

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against fyn
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Tyrosine-protein kinase Fyn (CHEMBL1841)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF.
Bioorg Med Chem Lett (2006) 16 : 118 -122
PubMed 16216497 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.92 5.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL371295 1 5.97
CHEMBL199438 1 4.87
CHEMBL440213 1 4.49
CHEMBL197603 1 4.36
CHEMBL199816 1 -
CHEMBL199813 1 -
CHEMBL381203 1 -
CHEMBL382939 1 -
CHEMBL370670 1 -
CHEMBL200424 1 -
CHEMBL200587 1 -
CHEMBL199369 1 -
CHEMBL371459 1 -
CHEMBL198239 1 -
CHEMBL373054 1 -
CHEMBL198136 1 -
CHEMBL370773 1 -
CHEMBL370383 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL371295 IC50 = 1070.0 nM 5.97
CHEMBL199438 IC50 = 13600.0 nM 4.87
CHEMBL440213 IC50 = 32500.0 nM 4.49
CHEMBL197603 IC50 = 44100.0 nM 4.36
CHEMBL199816 IC50 > 50000.0 nM -
CHEMBL199813 IC50 > 50000.0 nM -
CHEMBL381203 IC50 > 50000.0 nM -
CHEMBL382939 IC50 > 50000.0 nM -
CHEMBL370670 IC50 > 50000.0 nM -
CHEMBL200424 IC50 > 50000.0 nM -
CHEMBL200587 IC50 > 50000.0 nM -
CHEMBL199369 IC50 > 50000.0 nM -
CHEMBL371459 IC50 > 50000.0 nM -
CHEMBL198239 IC50 > 50000.0 nM -
CHEMBL373054 IC50 > 50000.0 nM -
CHEMBL198136 IC50 > 50000.0 nM -
CHEMBL370773 IC50 >= 50000.0 nM -
CHEMBL370383 IC50 > 50000.0 nM -