Assay Detail
Binding
CHEMBL864489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to non phosphorylated PIM1
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.71 | 8.85 |
| Kb | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 2 | 8.85 |
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | — | 2 | 8.10 |
| CHEMBL7463 | GF-109203 | — | 2 | 8.00 |
| CHEMBL269264 | — | — | 2 | 7.92 |
| CHEMBL200528 | — | — | 2 | 7.60 |
| CHEMBL50 | QUERCETIN | 3.0 | 2 | 7.60 |
| CHEMBL266487 | RO-316233 | — | 2 | 7.57 |
| CHEMBL370177 | — | — | 2 | 7.14 |
| CHEMBL372585 | — | — | 2 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL7463 | GF-109203 | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL269264 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL200528 | — | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL50 | QUERCETIN | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL266487 | RO-316233 | Kd | = | 27.0 | nM | 7.57 |
| CHEMBL370177 | — | Kd | = | 72.0 | nM | 7.14 |
| CHEMBL372585 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL7463 | GF-109203 | Kb | = | 98.6 | 10^6/M | - |
| CHEMBL200528 | — | Kb | = | 39.7 | 10^6/M | - |
| CHEMBL50 | QUERCETIN | Kb | = | 39.3 | 10^6/M | - |
| CHEMBL372585 | — | Kb | = | 4.0 | 10^6/M | - |
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | Kb | = | 127.0 | 10^6/M | - |
| CHEMBL269264 | — | Kb | = | 85.2 | 10^6/M | - |
| CHEMBL266487 | RO-316233 | Kb | = | 37.0 | 10^6/M | - |
| CHEMBL388978 | STAUROSPORINE | Kb | = | 705.0 | 10^6/M | - |
| CHEMBL370177 | — | Kb | = | 13.8 | 10^6/M | - |