Compound Detail
CHEMBL370177
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Basic Information
| ChEMBL ID | CHEMBL370177 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WCPRHIKZZFXHSD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
410.5
MW (Da)
3.21
ALogP
4
HBA
3
HBD
92.9
PSA (Ų)
0.45
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Kd | 7.14 | 7.14 | 72.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | Kd | = | 72.0 | nM | 7.14 | Binding affinity to non phosphorylated PIM1 | 16302800 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16302800 | 10.1021/jm0504858 | Serine/threonine-protein kinase pim-1 | 4 |
Data from ChEMBL 36 via Core Engine