Assay Detail
Binding
CHEMBL864505
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Inhibitory activity against human cathepsin K using Z-Leu-Arg-NHMec substrate
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 5.40 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200161 | — | — | 1 | 7.46 |
| CHEMBL200521 | — | — | 1 | 7.13 |
| CHEMBL200160 | — | — | 1 | 6.92 |
| CHEMBL344174 | — | — | 1 | 6.58 |
| CHEMBL200235 | — | — | 1 | 6.52 |
| CHEMBL381847 | — | — | 1 | 6.14 |
| CHEMBL383816 | — | — | 1 | 5.96 |
| CHEMBL200577 | — | — | 1 | 5.92 |
| CHEMBL383584 | — | — | 1 | 5.90 |
| CHEMBL371466 | — | — | 1 | 5.82 |
| CHEMBL200181 | — | — | 1 | 5.68 |
| CHEMBL200057 | — | — | 1 | 5.68 |
| CHEMBL200549 | — | — | 1 | 5.48 |
| CHEMBL371285 | — | — | 1 | 5.48 |
| CHEMBL424669 | — | — | 1 | 5.39 |
| CHEMBL200374 | — | — | 1 | 5.39 |
| CHEMBL200427 | — | — | 1 | 5.38 |
| CHEMBL200569 | — | — | 1 | 5.30 |
| CHEMBL370188 | — | — | 1 | 5.28 |
| CHEMBL197113 | — | — | 1 | 5.24 |
| CHEMBL372154 | — | — | 1 | 5.20 |
| CHEMBL371499 | — | — | 1 | 5.19 |
| CHEMBL200004 | — | — | 1 | 5.19 |
| CHEMBL197181 | — | — | 1 | 5.12 |
| CHEMBL198570 | — | — | 1 | 5.07 |
| CHEMBL200836 | — | — | 1 | 4.89 |
| CHEMBL200558 | — | — | 1 | 4.80 |
| CHEMBL380560 | — | — | 1 | 4.58 |
| CHEMBL200724 | — | — | 1 | 4.55 |
| CHEMBL381191 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200161 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL200521 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL200160 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL344174 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL200235 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL381847 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL383816 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL200577 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL383584 | — | Ki | = | 1270.0 | nM | 5.90 |
| CHEMBL371466 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL200181 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL200057 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL371285 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL200549 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL200374 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL424669 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL200427 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL200569 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL370188 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL197113 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL372154 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL371499 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL200004 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL197181 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL198570 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL200836 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL200558 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL380560 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL200724 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL381191 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL371893 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL383781 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL200285 | — | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL200557 | — | Ki | = | 83000.0 | nM | 4.08 |
| CHEMBL200574 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL200006 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL200635 | — | Ki | = | 136000.0 | nM | - |
| CHEMBL200007 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL197130 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL200576 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL200815 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL200743 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL200338 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL197498 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL197975 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL200005 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL200150 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL381659 | — | Ki | > | 100000.0 | nM | - |