Assay Detail
Binding
CHEMBL864506
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Inhibitory activity against human cathepsin L using Z-Phe-Arg-NHMec substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.43 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344174 | — | — | 1 | 6.64 |
| CHEMBL383781 | — | — | 1 | 6.54 |
| CHEMBL381191 | — | — | 1 | 6.37 |
| CHEMBL200374 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344174 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL383781 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL381191 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL200374 | — | Ki | = | 700.0 | nM | 6.16 |