Assay Detail
Binding
CHEMBL864516
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Binding affinity to adrenergic alpha-1 receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.38 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370594 | — | — | 1 | 8.92 |
| CHEMBL383564 | — | — | 1 | 8.79 |
| CHEMBL382057 | — | — | 1 | 8.70 |
| CHEMBL370863 | — | — | 1 | 8.66 |
| CHEMBL199876 | — | — | 1 | 8.58 |
| CHEMBL200802 | — | — | 1 | 8.55 |
| CHEMBL197656 | — | — | 1 | 8.48 |
| CHEMBL199875 | — | — | 1 | 8.39 |
| CHEMBL203362 | — | — | 1 | 8.33 |
| CHEMBL197968 | — | — | 1 | 8.30 |
| CHEMBL370125 | — | — | 1 | 8.26 |
| CHEMBL443567 | — | — | 1 | 8.20 |
| CHEMBL370364 | — | — | 1 | 7.93 |
| CHEMBL370136 | — | — | 1 | 7.79 |
| CHEMBL372222 | — | — | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370594 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL383564 | — | Ki | = | 1.63 | nM | 8.79 |
| CHEMBL382057 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL370863 | — | Ki | = | 2.18 | nM | 8.66 |
| CHEMBL199876 | — | Ki | = | 2.64 | nM | 8.58 |
| CHEMBL200802 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL197656 | — | Ki | = | 3.32 | nM | 8.48 |
| CHEMBL199875 | — | Ki | = | 4.08 | nM | 8.39 |
| CHEMBL203362 | — | Ki | = | 4.71 | nM | 8.33 |
| CHEMBL197968 | — | Ki | = | 4.97 | nM | 8.30 |
| CHEMBL370125 | — | Ki | = | 5.47 | nM | 8.26 |
| CHEMBL443567 | — | Ki | = | 6.28 | nM | 8.20 |
| CHEMBL370364 | — | Ki | = | 11.71 | nM | 7.93 |
| CHEMBL370136 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL372222 | — | Ki | = | 17.26 | nM | 7.76 |