Assay Detail
Binding
CHEMBL864517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to 5HT1A
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.44 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370863 | — | — | 1 | 7.72 |
| CHEMBL443567 | — | — | 1 | 7.19 |
| CHEMBL370125 | — | — | 1 | 6.95 |
| CHEMBL382057 | — | — | 1 | 6.91 |
| CHEMBL383564 | — | — | 1 | 6.80 |
| CHEMBL370594 | — | — | 1 | 6.53 |
| CHEMBL197968 | — | — | 1 | 6.48 |
| CHEMBL199875 | — | — | 1 | 6.40 |
| CHEMBL197656 | — | — | 1 | 5.99 |
| CHEMBL370136 | — | — | 1 | 5.97 |
| CHEMBL200802 | — | — | 1 | 5.84 |
| CHEMBL199876 | — | — | 1 | 5.82 |
| CHEMBL203362 | — | — | 1 | 5.81 |
| CHEMBL370364 | — | — | 1 | 5.74 |
| CHEMBL372222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370863 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL443567 | — | Ki | = | 64.9 | nM | 7.19 |
| CHEMBL370125 | — | Ki | = | 113.4 | nM | 6.95 |
| CHEMBL382057 | — | Ki | = | 122.3 | nM | 6.91 |
| CHEMBL383564 | — | Ki | = | 157.3 | nM | 6.80 |
| CHEMBL370594 | — | Ki | = | 295.1 | nM | 6.53 |
| CHEMBL197968 | — | Ki | = | 333.34 | nM | 6.48 |
| CHEMBL199875 | — | Ki | = | 401.3 | nM | 6.40 |
| CHEMBL197656 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL370136 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL200802 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL199876 | — | Ki | = | 1513.0 | nM | 5.82 |
| CHEMBL203362 | — | Ki | = | 1540.0 | nM | 5.81 |
| CHEMBL370364 | — | Ki | = | 1815.0 | nM | 5.74 |
| CHEMBL372222 | — | Ki | > | 10000.0 | nM | - |