Assay Detail
Binding
CHEMBL864532
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Inhibitory activity against caspase 3 using Ac-DEVD-AMC substrate
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.78 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372322 | — | — | 1 | 8.41 |
| CHEMBL198755 | — | — | 1 | 8.36 |
| CHEMBL197549 | — | — | 1 | 8.28 |
| CHEMBL371687 | — | — | 1 | 8.24 |
| CHEMBL198682 | — | — | 1 | 8.08 |
| CHEMBL200813 | — | — | 1 | 8.08 |
| CHEMBL200886 | — | — | 1 | 8.06 |
| CHEMBL372994 | — | — | 1 | 8.04 |
| CHEMBL200493 | — | — | 1 | 8.03 |
| CHEMBL200785 | — | — | 1 | 8.01 |
| CHEMBL200653 | — | — | 1 | 7.99 |
| CHEMBL370012 | — | — | 1 | 7.96 |
| CHEMBL382084 | — | — | 1 | 7.95 |
| CHEMBL200476 | — | — | 1 | 7.92 |
| CHEMBL372607 | — | — | 1 | 7.92 |
| CHEMBL200220 | — | — | 1 | 7.91 |
| CHEMBL439753 | — | — | 1 | 7.91 |
| CHEMBL200927 | — | — | 1 | 7.87 |
| CHEMBL200677 | — | — | 1 | 7.84 |
| CHEMBL197237 | — | — | 1 | 7.69 |
| CHEMBL373012 | — | — | 1 | 7.67 |
| CHEMBL371879 | — | — | 1 | 7.63 |
| CHEMBL196855 | — | — | 1 | 7.54 |
| CHEMBL197535 | — | — | 1 | 7.23 |
| CHEMBL371709 | — | — | 1 | 7.04 |
| CHEMBL293034 | — | — | 1 | 6.92 |
| CHEMBL62993 | — | — | 1 | 6.62 |
| CHEMBL200767 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372322 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL198755 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL197549 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL371687 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL198682 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL200813 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL200886 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL372994 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL200493 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL200785 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL200653 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL370012 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL382084 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL200476 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL372607 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL200220 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL439753 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL200927 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL200677 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL197237 | — | IC50 | = | 20.4 | nM | 7.69 |
| CHEMBL373012 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL371879 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL196855 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL197535 | — | IC50 | = | 58.3 | nM | 7.23 |
| CHEMBL371709 | — | IC50 | = | 91.7 | nM | 7.04 |
| CHEMBL293034 | — | IC50 | = | 119.2 | nM | 6.92 |
| CHEMBL62993 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL200767 | — | IC50 | = | 286.7 | nM | 6.54 |