Assay Detail
Binding
CHEMBL864546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against recombinant human adenosine kinase
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.75 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370164 | — | — | 1 | 9.70 |
| CHEMBL100421 | — | — | 1 | 9.30 |
| CHEMBL426472 | — | — | 1 | 9.30 |
| CHEMBL370011 | — | — | 1 | 9.30 |
| CHEMBL200169 | — | — | 1 | 9.22 |
| CHEMBL200630 | — | — | 1 | 9.10 |
| CHEMBL198566 | — | — | 1 | 9.05 |
| CHEMBL438449 | — | — | 1 | 9.00 |
| CHEMBL370654 | — | — | 1 | 8.89 |
| CHEMBL372796 | — | — | 1 | 8.89 |
| CHEMBL66277 | — | — | 1 | 8.82 |
| CHEMBL197112 | — | — | 1 | 8.70 |
| CHEMBL200575 | — | — | 1 | 8.70 |
| CHEMBL371909 | — | — | 1 | 8.52 |
| CHEMBL198635 | — | — | 1 | 8.52 |
| CHEMBL435123 | — | — | 1 | 8.40 |
| CHEMBL371044 | — | — | 1 | 8.40 |
| CHEMBL438796 | — | — | 1 | 8.30 |
| CHEMBL436096 | — | — | 1 | 8.22 |
| CHEMBL381229 | — | — | 1 | 8.22 |
| CHEMBL200219 | — | — | 1 | 8.15 |
| CHEMBL200457 | — | — | 1 | 8.00 |
| CHEMBL197072 | — | — | 1 | 7.80 |
| CHEMBL200196 | — | — | 1 | 7.70 |
| CHEMBL425752 | — | — | 1 | 7.60 |
| CHEMBL198972 | — | — | 1 | 7.57 |
| CHEMBL371950 | — | — | 1 | 7.42 |
| CHEMBL381407 | — | — | 1 | 7.40 |
| CHEMBL200620 | — | — | 1 | 7.35 |
| CHEMBL199371 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370164 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL100421 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL370011 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL426472 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL200169 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL200630 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL198566 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL438449 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL370654 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL372796 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL66277 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL197112 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL200575 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL371909 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL198635 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL435123 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL371044 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL438796 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL436096 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL381229 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL200219 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL200457 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL197072 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL200196 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL425752 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL198972 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL371950 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL381407 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL200620 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL199371 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL198742 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL196955 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL382911 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL198698 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL382451 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL329484 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL381005 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL372155 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL200393 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL200352 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL98174 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL383388 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL382751 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL371924 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL371549 | — | IC50 | > | 10000.0 | nM | - |