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Assay Detail

CHEMBL864614

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Binding
Inhibitory activity against anthrax lethal factor metalloprotease
ChEMBL ↗
60
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 9 — Direct single protein target
Curated By Expert

Target

Lethal factor (CHEMBL4372) ↗
Type SINGLE PROTEIN
Organism Bacillus anthracis

Publication

Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies.
Johnson SL, Jung D, Forino M, Chen Y, Satterthwait A, Rozanov DV, Strongin AY, Pellecchia M.
J Med Chem (2006) 49 : 27 -30
PubMed 16392787 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 60 5.50 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL371478 — — 2 6.72
CHEMBL199390 — — 2 6.58
CHEMBL372792 — — 2 6.53
CHEMBL201404 — — 2 6.30
CHEMBL200421 — — 2 6.13
CHEMBL381845 — — 2 6.07
CHEMBL427195 — — 2 6.05
CHEMBL199465 — — 2 5.92
CHEMBL199941 — — 2 5.89
CHEMBL200222 — — 2 5.80
CHEMBL200022 CLAFICAPAVIR 2.0 2 5.77
CHEMBL200850 — — 2 5.68
CHEMBL200384 — — 2 5.64
CHEMBL199659 — — 2 5.52
CHEMBL381215 — — 2 5.51
CHEMBL200716 — — 2 5.50
CHEMBL201020 — — 2 5.36
CHEMBL200192 — — 2 5.36
CHEMBL199584 — — 2 5.30
CHEMBL197764 — — 2 5.25
CHEMBL446705 — — 2 5.25
CHEMBL276126 — — 2 5.23
CHEMBL200013 — — 2 5.00
CHEMBL200605 — — 2 4.78
CHEMBL198289 — — 2 4.65
CHEMBL373276 — — 2 4.14
CHEMBL380982 — — 2 4.10
CHEMBL197810 — — 2 4.00
CHEMBL200848 — — 2 -
CHEMBL199772 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL371478 — IC50 = 190.0 nM 6.72
CHEMBL371478 — IC50 = 194.98 nM 6.71
CHEMBL199390 — IC50 = 263.03 nM 6.58
CHEMBL199390 — IC50 = 260.0 nM 6.58
CHEMBL372792 — IC50 = 295.12 nM 6.53
CHEMBL372792 — IC50 = 300.0 nM 6.52
CHEMBL201404 — IC50 = 501.19 nM 6.30
CHEMBL201404 — IC50 = 500.0 nM 6.30
CHEMBL200421 — IC50 = 741.31 nM 6.13
CHEMBL200421 — IC50 = 740.0 nM 6.13
CHEMBL381845 — IC50 = 850.0 nM 6.07
CHEMBL381845 — IC50 = 851.14 nM 6.07
CHEMBL427195 — IC50 = 891.25 nM 6.05
CHEMBL427195 — IC50 = 900.0 nM 6.05
CHEMBL199465 — IC50 = 1200.0 nM 5.92
CHEMBL199465 — IC50 = 1202.26 nM 5.92
CHEMBL199941 — IC50 = 1300.0 nM 5.89
CHEMBL199941 — IC50 = 1288.25 nM 5.89
CHEMBL200222 — IC50 = 1584.89 nM 5.80
CHEMBL200222 — IC50 = 1600.0 nM 5.80
CHEMBL200022 CLAFICAPAVIR IC50 = 1698.24 nM 5.77
CHEMBL200022 CLAFICAPAVIR IC50 = 1700.0 nM 5.77
CHEMBL200850 — IC50 = 2089.3 nM 5.68
CHEMBL200850 — IC50 = 2100.0 nM 5.68
CHEMBL200384 — IC50 = 2290.87 nM 5.64
CHEMBL200384 — IC50 = 2300.0 nM 5.64
CHEMBL199659 — IC50 = 3000.0 nM 5.52
CHEMBL199659 — IC50 = 3019.95 nM 5.52
CHEMBL381215 — IC50 = 3090.3 nM 5.51
CHEMBL381215 — IC50 = 3100.0 nM 5.51
CHEMBL200716 — IC50 = 3200.0 nM 5.50
CHEMBL200716 — IC50 = 3235.94 nM 5.49
CHEMBL200192 — IC50 = 4400.0 nM 5.36
CHEMBL201020 — IC50 = 4400.0 nM 5.36
CHEMBL201020 — IC50 = 4365.16 nM 5.36
CHEMBL200192 — IC50 = 4365.16 nM 5.36
CHEMBL199584 — IC50 = 5011.87 nM 5.30
CHEMBL199584 — IC50 = 5000.0 nM 5.30
CHEMBL197764 — IC50 = 5600.0 nM 5.25
CHEMBL446705 — IC50 = 5623.41 nM 5.25
CHEMBL446705 — IC50 = 5600.0 nM 5.25
CHEMBL197764 — IC50 = 5623.41 nM 5.25
CHEMBL276126 — IC50 = 5888.44 nM 5.23
CHEMBL276126 — IC50 = 5900.0 nM 5.23
CHEMBL200013 — IC50 = 10000.0 nM 5.00
CHEMBL200013 — IC50 = 10000.0 nM 5.00
CHEMBL200605 — IC50 = 16595.87 nM 4.78
CHEMBL200605 — IC50 = 16600.0 nM 4.78
CHEMBL198289 — IC50 = 22387.21 nM 4.65
CHEMBL198289 — IC50 = 22400.0 nM 4.65