Compound Detail
CHEMBL200022
CLAFICAPAVIR 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL200022 |
| Name | CLAFICAPAVIR |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | YZLFZFALAZYTCI-ZROIWOOFSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
2
Known Names
1
Indications
Molecular Properties
393.9
MW (Da)
4.28
ALogP
5
HBA
1
HBD
70.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Virus Diseases
Activity Summary
IC50 2 meas. best 5.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lethal factor CHEMBL4372 | IC50 | 5.77 | 5.77 | 1698.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lethal factor | IC50 | = | 1700.0 | nM | 5.77 | Inhibitory activity against anthrax lethal factor metalloprotease | 16392787 |
| Lethal factor | IC50 | = | 1698.24 | nM | 5.77 | Inhibitory activity against anthrax lethal factor metalloprotease | 16392787 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16392787 | 10.1021/jm050892j | Lethal factor | 2 |
Data from ChEMBL 36 via Core Engine