Assay Detail
Binding
CHEMBL864629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BuChE from horse serum
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.00 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199670 | — | — | 1 | 9.02 |
| CHEMBL199454 | — | — | 1 | 8.70 |
| CHEMBL382260 | — | — | 1 | 8.60 |
| CHEMBL370807 | — | — | 1 | 8.46 |
| CHEMBL383663 | — | — | 1 | 8.28 |
| CHEMBL199538 | — | — | 1 | 8.09 |
| CHEMBL381499 | — | — | 1 | 8.09 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.00 |
| CHEMBL199861 | — | — | 1 | 7.92 |
| CHEMBL202661 | — | — | 1 | 7.82 |
| CHEMBL200008 | — | — | 1 | 7.66 |
| CHEMBL199748 | — | — | 1 | 7.26 |
| CHEMBL199585 | — | — | 1 | 7.07 |
| CHEMBL372202 | — | — | 1 | 7.00 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199670 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL199454 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL382260 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL370807 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL383663 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL199538 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL381499 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL95 | TACRINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL199861 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL202661 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL200008 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL199748 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL199585 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL372202 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL45 | MELATONIN | IC50 | > | 100.0 | nM | - |