Assay Detail
Binding
CHEMBL864690
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Displacement of [33P]S1P from human S1P3 receptor expressed in CHO cells
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.78 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208648 | — | — | 1 | 6.34 |
| CHEMBL425563 | — | — | 1 | 6.28 |
| CHEMBL208838 | — | — | 2 | 6.16 |
| CHEMBL378061 | — | — | 1 | 5.82 |
| CHEMBL377855 | — | — | 1 | 5.68 |
| CHEMBL377828 | — | — | 1 | 5.51 |
| CHEMBL377968 | — | — | 1 | 5.32 |
| CHEMBL194419 | — | — | 1 | 4.92 |
| CHEMBL425602 | — | — | 1 | - |
| CHEMBL211006 | — | — | 1 | - |
| CHEMBL378300 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208648 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL425563 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL208838 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL208838 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL378061 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL377855 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL377828 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL377968 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL194419 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL425602 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL211006 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL378300 | — | IC50 | > | 1000.0 | nM | - |