Assay Detail
Binding
CHEMBL864763
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Binding affinity to rabbit f10a
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.21 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | -1.0 | 1 | 9.72 |
| CHEMBL384526 | — | — | 1 | 9.00 |
| CHEMBL213352 | — | — | 1 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL384526 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL213352 | — | Ki | = | 1.2 | nM | 8.92 |