Assay Detail
Functional
CHEMBL864803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu opioid receptor by guinea pig ileum assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.65 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501451 | — | — | 1 | 8.59 |
| CHEMBL458631 | — | — | 1 | 8.57 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 7.86 |
| CHEMBL2375157 | — | — | 1 | 7.57 |
| CHEMBL208683 | — | — | 1 | 7.29 |
| CHEMBL377392 | — | — | 1 | 7.02 |
| CHEMBL211543 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501451 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL458631 | — | IC50 | = | 2.69 | nM | 8.57 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL2375157 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL208683 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL377392 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL211543 | — | IC50 | = | 231.0 | nM | 6.64 |