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Assay Detail

CHEMBL864855

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Binding
Inhibition of human Wee1 in presence of 9.5 uM ATP
ChEMBL ↗
103
Total Activities
103
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Wee1-like protein kinase (CHEMBL5491) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.
Palmer BD, Thompson AM, Booth RJ, Dobrusin EM, Kraker AJ, Lee HH, Lunney EA, Mitchell LH, Ortwine DF, Smaill JB, Swan LM, Denny WA.
J Med Chem (2006) 49 : 4896 -4911
PubMed 16884302 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 103 6.59 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL379975 — — 1 7.96
CHEMBL213585 — — 1 7.92
CHEMBL215815 — — 1 7.89
CHEMBL215485 — — 1 7.82
CHEMBL386048 — — 1 7.75
CHEMBL384089 — — 1 7.72
CHEMBL211140 — — 1 7.70
CHEMBL378066 — — 1 7.70
CHEMBL213313 — — 1 7.68
CHEMBL215677 — — 1 7.64
CHEMBL213367 — — 1 7.64
CHEMBL209594 — — 1 7.62
CHEMBL213075 — — 1 7.62
CHEMBL386199 — — 1 7.57
CHEMBL213593 — — 1 7.55
CHEMBL384477 — — 1 7.55
CHEMBL214090 — — 1 7.54
CHEMBL386398 — — 1 7.48
CHEMBL215506 — — 1 7.48
CHEMBL378067 — — 1 7.46
CHEMBL213422 — — 1 7.42
CHEMBL214208 — — 1 7.38
CHEMBL377839 — — 1 7.38
CHEMBL379732 — — 1 7.35
CHEMBL209786 — — 1 7.33
CHEMBL379392 — — 1 7.31
CHEMBL379825 — — 1 7.30
CHEMBL213525 — — 1 7.28
CHEMBL212495 — — 1 7.26
CHEMBL209388 — — 1 7.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL379975 — IC50 = 11.0 nM 7.96
CHEMBL213585 — IC50 = 12.0 nM 7.92
CHEMBL215815 — IC50 = 13.0 nM 7.89
CHEMBL215485 — IC50 = 15.0 nM 7.82
CHEMBL386048 — IC50 = 18.0 nM 7.75
CHEMBL384089 — IC50 = 19.0 nM 7.72
CHEMBL211140 — IC50 = 20.0 nM 7.70
CHEMBL378066 — IC50 = 20.0 nM 7.70
CHEMBL213313 — IC50 = 21.0 nM 7.68
CHEMBL213367 — IC50 = 23.0 nM 7.64
CHEMBL215677 — IC50 = 23.0 nM 7.64
CHEMBL213075 — IC50 = 24.0 nM 7.62
CHEMBL209594 — IC50 = 24.0 nM 7.62
CHEMBL386199 — IC50 = 27.0 nM 7.57
CHEMBL384477 — IC50 = 28.0 nM 7.55
CHEMBL213593 — IC50 = 28.0 nM 7.55
CHEMBL214090 — IC50 = 29.0 nM 7.54
CHEMBL386398 — IC50 = 33.0 nM 7.48
CHEMBL215506 — IC50 = 33.0 nM 7.48
CHEMBL378067 — IC50 = 35.0 nM 7.46
CHEMBL213422 — IC50 = 38.0 nM 7.42
CHEMBL214208 — IC50 = 42.0 nM 7.38
CHEMBL377839 — IC50 = 42.0 nM 7.38
CHEMBL379732 — IC50 = 45.0 nM 7.35
CHEMBL209786 — IC50 = 47.0 nM 7.33
CHEMBL379392 — IC50 = 49.0 nM 7.31
CHEMBL379825 — IC50 = 50.0 nM 7.30
CHEMBL213525 — IC50 = 53.0 nM 7.28
CHEMBL212495 — IC50 = 55.0 nM 7.26
CHEMBL209388 — IC50 = 57.0 nM 7.24
CHEMBL215900 — IC50 = 59.0 nM 7.23
CHEMBL212594 — IC50 = 60.0 nM 7.22
CHEMBL212646 — IC50 = 63.0 nM 7.20
CHEMBL212660 — IC50 = 67.0 nM 7.17
CHEMBL212797 — IC50 = 70.0 nM 7.16
CHEMBL385194 — IC50 = 75.0 nM 7.12
CHEMBL378756 — IC50 = 78.0 nM 7.11
CHEMBL214140 — IC50 = 89.0 nM 7.05
CHEMBL214253 — IC50 = 97.0 nM 7.01
CHEMBL424888 — IC50 = 110.0 nM 6.96
CHEMBL214341 — IC50 = 130.0 nM 6.89
CHEMBL209486 — IC50 = 140.0 nM 6.85
CHEMBL211929 — IC50 = 150.0 nM 6.82
CHEMBL384831 — IC50 = 150.0 nM 6.82
CHEMBL384829 — IC50 = 150.0 nM 6.82
CHEMBL384103 — IC50 = 160.0 nM 6.80
CHEMBL214137 — IC50 = 170.0 nM 6.77
CHEMBL413579 — IC50 = 180.0 nM 6.75
CHEMBL379149 — IC50 = 180.0 nM 6.75
CHEMBL209448 — IC50 = 190.0 nM 6.72