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Assay Detail

CHEMBL864864

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Intermediate

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and hypoxic-cytotoxic activity of some 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Jiang F, Yang B, Fan L, He Q, Hu Y.
Bioorg Med Chem Lett (2006) 16 : 4209 -4213
PubMed 16777409 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.37 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL211782 1 6.05
CHEMBL380033 1 5.85
CHEMBL448731 1 5.82
CHEMBL425426 1 5.60
CHEMBL209539 1 5.60
CHEMBL369752 1 5.54
CHEMBL214298 1 5.44
CHEMBL209540 1 5.24
CHEMBL50882 TIRAPAZAMINE 3.0 1 5.16
CHEMBL211526 1 5.14
CHEMBL214051 1 5.08
CHEMBL214041 1 5.05
CHEMBL214158 1 4.97
CHEMBL210182 1 4.59
CHEMBL373611 1 -
CHEMBL215795 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL211782 IC50 = 900.0 nM 6.05
CHEMBL380033 IC50 = 1400.0 nM 5.85
CHEMBL448731 IC50 = 1500.0 nM 5.82
CHEMBL425426 IC50 = 2500.0 nM 5.60
CHEMBL209539 IC50 = 2500.0 nM 5.60
CHEMBL369752 IC50 = 2900.0 nM 5.54
CHEMBL214298 IC50 = 3600.0 nM 5.44
CHEMBL209540 IC50 = 5800.0 nM 5.24
CHEMBL50882 TIRAPAZAMINE IC50 = 7000.0 nM 5.16
CHEMBL211526 IC50 = 7200.0 nM 5.14
CHEMBL214051 IC50 = 8300.0 nM 5.08
CHEMBL214041 IC50 = 9000.0 nM 5.05
CHEMBL214158 IC50 = 10700.0 nM 4.97
CHEMBL210182 IC50 = 25800.0 nM 4.59
CHEMBL373611 IC50 > 49000.0 nM -
CHEMBL215795 IC50 > 60000.0 nM -