Assay Detail
Binding
CHEMBL864918
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Displacement of [125I]galanin from human GAL3
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.80 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210288 | — | — | 1 | 7.77 |
| CHEMBL211169 | — | — | 1 | 7.28 |
| CHEMBL387401 | — | — | 1 | 7.05 |
| CHEMBL212729 | — | — | 1 | 6.82 |
| CHEMBL378877 | — | — | 1 | 6.36 |
| CHEMBL209480 | — | — | 1 | 6.22 |
| CHEMBL209737 | — | — | 1 | 6.07 |
| CHEMBL378695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210288 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL211169 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL387401 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL212729 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL378877 | — | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL209480 | — | Ki | = | 596.0 | nM | 6.22 |
| CHEMBL209737 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL378695 | — | Ki | > | 10000.0 | nM | - |