Assay Detail
Functional
CHEMBL864933
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Inhibition of MCP1-induced chemotaxis of human monocytes
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.12 | 8.02 |
| Kb | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211775 | — | — | 1 | 8.02 |
| CHEMBL211225 | — | — | 1 | 7.22 |
| CHEMBL376981 | — | — | 1 | 7.22 |
| CHEMBL209263 | — | — | 1 | 6.00 |
| CHEMBL432713 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211775 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL211225 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL376981 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL209263 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL432713 | — | Kb | = | 25.0 | nM | - |