Assay Detail
Binding
CHEMBL864944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.16 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.38 |
| CHEMBL209034 | — | — | 1 | 5.82 |
| CHEMBL207543 | — | — | 1 | 5.66 |
| CHEMBL378680 | — | — | 1 | 5.64 |
| CHEMBL210341 | — | — | 1 | 5.60 |
| CHEMBL208274 | — | — | 1 | 5.54 |
| CHEMBL211135 | — | — | 1 | 5.26 |
| CHEMBL211539 | — | — | 1 | 5.25 |
| CHEMBL211590 | — | — | 1 | 5.23 |
| CHEMBL211118 | — | — | 1 | 5.19 |
| CHEMBL379125 | — | — | 1 | 5.19 |
| CHEMBL212370 | — | — | 1 | 5.17 |
| CHEMBL207488 | — | — | 1 | 5.16 |
| CHEMBL211164 | — | — | 1 | 5.15 |
| CHEMBL378515 | — | — | 1 | 5.11 |
| CHEMBL380054 | — | — | 1 | 5.08 |
| CHEMBL143761 | — | — | 1 | 5.07 |
| CHEMBL210551 | — | — | 1 | 5.06 |
| CHEMBL7927 | FAUC 113 | — | 1 | 4.92 |
| CHEMBL380287 | — | — | 1 | 4.89 |
| CHEMBL140099 | — | — | 1 | 4.89 |
| CHEMBL377542 | — | — | 1 | 4.82 |
| CHEMBL212631 | — | — | 1 | 4.70 |
| CHEMBL212160 | — | — | 1 | 4.57 |
| CHEMBL210283 | — | — | 1 | 4.40 |
| CHEMBL425064 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL209034 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL207543 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL378680 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL210341 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL208274 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL211135 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL211539 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL211590 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL211118 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL379125 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL212370 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL207488 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL211164 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL378515 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL380054 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL143761 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL210551 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL7927 | FAUC 113 | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL380287 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL140099 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL377542 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL212631 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL212160 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL210283 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL425064 | — | Ki | = | 47000.0 | nM | 4.33 |