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Compound Detail

CHEMBL211118

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COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1

Basic Information

ChEMBL ID CHEMBL211118
Phase Preclinical
Structure Type MOL
InChI Key UKYZTZPUJPHXDZ-UHFFFAOYSA-N
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

421.6
MW (Da)
2.81
ALogP
7
HBA
0
HBD
45.5
PSA (Ų)
0.63
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H31N5O2
MW 421.55
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -1.69

Activity Summary

Ki 5 meas. best 8.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
Ki 8.64 8.64 2.3 1
D(2) dopamine receptor
CHEMBL217
Ki 7.0 6.84 100.0 2
D(3) dopamine receptor
CHEMBL234
Ki 5.68 5.68 2100.0 1
D(1A) dopamine receptor
CHEMBL5067
Ki 5.19 5.19 6400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16789750 10.1021/jm060166w D(2) dopamine receptor 2
16789750 10.1021/jm060166w Adrenergic receptor alpha-1 1
16789750 10.1021/jm060166w 5-hydroxytryptamine receptor 2A 1
16789750 10.1021/jm060166w 5-hydroxytryptamine receptor 1A 1
16789750 10.1021/jm060166w D(4) dopamine receptor 1
16789750 10.1021/jm060166w D(3) dopamine receptor 1
16789750 10.1021/jm060166w D(1A) dopamine receptor 1

Data from ChEMBL 36 via Core Engine