Assay Detail
Binding
CHEMBL866801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.63 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208274 | — | — | 1 | 6.41 |
| CHEMBL211590 | — | — | 1 | 6.33 |
| CHEMBL379125 | — | — | 1 | 6.22 |
| CHEMBL211539 | — | — | 1 | 6.17 |
| CHEMBL211164 | — | — | 1 | 6.10 |
| CHEMBL207543 | — | — | 1 | 6.07 |
| CHEMBL380287 | — | — | 1 | 6.06 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.02 |
| CHEMBL212160 | — | — | 1 | 6.00 |
| CHEMBL210341 | — | — | 1 | 6.00 |
| CHEMBL378515 | — | — | 1 | 5.85 |
| CHEMBL209034 | — | — | 1 | 5.82 |
| CHEMBL378680 | — | — | 1 | 5.77 |
| CHEMBL140099 | — | — | 1 | 5.77 |
| CHEMBL211118 | — | — | 1 | 5.68 |
| CHEMBL210551 | — | — | 1 | 5.62 |
| CHEMBL380054 | — | — | 1 | 5.51 |
| CHEMBL210283 | — | — | 1 | 5.46 |
| CHEMBL212631 | — | — | 1 | 5.41 |
| CHEMBL7927 | FAUC 113 | — | 1 | 5.30 |
| CHEMBL207488 | — | — | 1 | 5.25 |
| CHEMBL211135 | — | — | 1 | 5.11 |
| CHEMBL212370 | — | — | 1 | 5.06 |
| CHEMBL143761 | — | — | 1 | 4.82 |
| CHEMBL377542 | — | — | 1 | 4.38 |
| CHEMBL425064 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208274 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL211590 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL379125 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL211539 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL211164 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL207543 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL380287 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL42 | CLOZAPINE | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL212160 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL210341 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL378515 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL209034 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL378680 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL140099 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL211118 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL210551 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL380054 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL210283 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL212631 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL7927 | FAUC 113 | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL207488 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL211135 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL212370 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL143761 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL377542 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL425064 | — | Ki | = | 60000.0 | nM | 4.22 |