Assay Detail
Binding
CHEMBL864971
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Inhibition of VEGFR2 phosphorylation in presence of 2 uM ATP by HTRF assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of VEGF receptors-1 and -2 based on the 2-((pyridin-4-yl)ethyl)pyridine template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.70 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202011 | — | — | 1 | 7.82 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.66 |
| CHEMBL205502 | — | — | 1 | 7.51 |
| CHEMBL153843 | — | — | 1 | 7.50 |
| CHEMBL205325 | — | — | 1 | 7.37 |
| CHEMBL380536 | — | — | 1 | 7.36 |
| CHEMBL377995 | — | — | 1 | 7.29 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 7.27 |
| CHEMBL381182 | — | — | 1 | 7.24 |
| CHEMBL383334 | — | — | 1 | 7.19 |
| CHEMBL382610 | — | — | 1 | 7.17 |
| CHEMBL206123 | — | — | 1 | 7.16 |
| CHEMBL383123 | — | — | 1 | 7.07 |
| CHEMBL382218 | — | — | 1 | 7.06 |
| CHEMBL205050 | — | — | 1 | 6.77 |
| CHEMBL204984 | — | — | 1 | 6.72 |
| CHEMBL205544 | — | — | 1 | 6.66 |
| CHEMBL207975 | — | — | 1 | 6.60 |
| CHEMBL208363 | — | — | 1 | 6.54 |
| CHEMBL383333 | — | — | 1 | 6.51 |
| CHEMBL383434 | — | — | 1 | 6.46 |
| CHEMBL207772 | — | — | 1 | 6.44 |
| CHEMBL206136 | — | — | 1 | 6.42 |
| CHEMBL382142 | — | — | 1 | 6.36 |
| CHEMBL205244 | — | — | 1 | 6.36 |
| CHEMBL205639 | — | — | 1 | 6.33 |
| CHEMBL381293 | — | — | 1 | 6.26 |
| CHEMBL381577 | — | — | 1 | 6.25 |
| CHEMBL205421 | — | — | 1 | 6.14 |
| CHEMBL204425 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202011 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL205502 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL153843 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL205325 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL380536 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL377995 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL101253 | VATALANIB | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL381182 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL383334 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL382610 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL206123 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL383123 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL382218 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL205050 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL204984 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL205544 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL207975 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL208363 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL383333 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL383434 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL207772 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL206136 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL205244 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL382142 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL205639 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL381293 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL381577 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL205421 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL204425 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL204621 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL208229 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL382797 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL205647 | — | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL205901 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL205869 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL381704 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL204846 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206670 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL206089 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL205684 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL207099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL207049 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL207821 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL380421 | — | IC50 | > | 10000.0 | nM | - |