Assay Detail
Binding
CHEMBL865083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKK alpha
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHEMBL3476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.95 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377085 | — | — | 1 | 5.55 |
| CHEMBL207012 | — | — | 1 | 4.68 |
| CHEMBL207071 | — | — | 1 | 4.62 |
| CHEMBL377928 | — | — | 1 | - |
| CHEMBL207987 | — | — | 1 | - |
| CHEMBL207028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377085 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL207012 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL207071 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL377928 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL207987 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL207028 | — | IC50 | > | 30000.0 | nM | - |