Assay Detail
Binding
CHEMBL865149
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Inhibition of HDAC in rat liver homogenate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.66 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203207 | — | — | 1 | 7.40 |
| CHEMBL201473 | — | — | 1 | 7.22 |
| CHEMBL371212 | — | — | 1 | 6.96 |
| CHEMBL203028 | — | — | 1 | 6.92 |
| CHEMBL198350 | — | — | 1 | 6.82 |
| CHEMBL383285 | — | — | 1 | 6.80 |
| CHEMBL201710 | — | — | 1 | 6.75 |
| CHEMBL203421 | — | — | 1 | 6.62 |
| CHEMBL200980 | — | — | 1 | 6.58 |
| CHEMBL199713 | — | — | 1 | 6.51 |
| CHEMBL380339 | — | — | 1 | 6.47 |
| CHEMBL201131 | — | — | 1 | 6.42 |
| CHEMBL381561 | — | — | 1 | 6.41 |
| CHEMBL203036 | — | — | 1 | 6.40 |
| CHEMBL201075 | — | — | 1 | 6.39 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.36 |
| CHEMBL199665 | — | — | 1 | 6.16 |
| CHEMBL380443 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203207 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL201473 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL371212 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL203028 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL198350 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL383285 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL201710 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL203421 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL200980 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL199713 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL380339 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL201131 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL381561 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL203036 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL201075 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL199665 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL380443 | — | IC50 | > | 25000.0 | nM | - |