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Assay Detail

CHEMBL865151

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of human leukemic CEM cell viability
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCRF-CEM
Confidence 1 — Organism
Curated By Expert

Target

CCRF-CEM (CHEMBL382)
Type CELL-LINE
Organism Homo sapiens

Publication

Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides.
Marson CM, Savy P, Rioja AS, Mahadevan T, Mikol C, Veerupillai A, Nsubuga E, Chahwan A, Joel SP.
J Med Chem (2006) 49 : 800 -805
PubMed 16420064 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.43 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL199713 1 5.80
CHEMBL199665 1 5.77
CHEMBL98 VORINOSTAT 4.0 1 5.72
CHEMBL198350 1 5.58
CHEMBL383285 1 5.47
CHEMBL201710 1 5.47
CHEMBL380339 1 5.12
CHEMBL201075 1 5.02
CHEMBL201131 1 4.91
CHEMBL380443 1 -
CHEMBL203036 1 -
CHEMBL371212 1 -
CHEMBL200980 1 -
CHEMBL203421 1 -
CHEMBL381561 1 -
CHEMBL203207 1 -
CHEMBL201473 1 -
CHEMBL203028 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL199713 IC50 = 1600.0 nM 5.80
CHEMBL199665 IC50 = 1700.0 nM 5.77
CHEMBL98 VORINOSTAT IC50 = 1900.0 nM 5.72
CHEMBL198350 IC50 = 2600.0 nM 5.58
CHEMBL383285 IC50 = 3400.0 nM 5.47
CHEMBL201710 IC50 = 3400.0 nM 5.47
CHEMBL380339 IC50 = 7500.0 nM 5.12
CHEMBL201075 IC50 = 9600.0 nM 5.02
CHEMBL201131 IC50 = 12300.0 nM 4.91
CHEMBL380443 IC50 - -
CHEMBL203036 IC50 - -
CHEMBL371212 IC50 > 25000.0 nM -
CHEMBL200980 IC50 > 25000.0 nM -
CHEMBL203421 IC50 - -
CHEMBL381561 IC50 - -
CHEMBL203207 IC50 > 25000.0 nM -
CHEMBL201473 IC50 > 25000.0 nM -
CHEMBL203028 IC50 > 25000.0 nM -