Assay Detail
Functional
CHEMBL865333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Efficacy against TRAF-alpha-1 reporter cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.07 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557 | DETROTHYRONINE | 2.0 | 1 | 8.89 |
| CHEMBL203828 | — | — | 1 | 8.39 |
| CHEMBL203777 | — | — | 1 | 8.00 |
| CHEMBL425939 | — | — | 1 | 8.00 |
| CHEMBL203555 | — | — | 1 | 7.08 |
| CHEMBL378593 | — | — | 1 | - |
| CHEMBL251439 | — | — | 1 | - |
| CHEMBL250880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557 | DETROTHYRONINE | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL203828 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL203777 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL425939 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL203555 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL378593 | — | EC50 | - | — | - | |
| CHEMBL251439 | — | EC50 | - | — | - | |
| CHEMBL250880 | — | EC50 | - | — | - |