Assay Detail
Binding
CHEMBL865438
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Inhibition of COX2 in canine whole blood
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.25 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378649 | — | — | 1 | 8.00 |
| CHEMBL380148 | — | — | 1 | 8.00 |
| CHEMBL383064 | — | — | 1 | 7.92 |
| CHEMBL205351 | — | — | 1 | 7.89 |
| CHEMBL380457 | — | — | 1 | 7.72 |
| CHEMBL206359 | — | — | 1 | 7.70 |
| CHEMBL381834 | — | — | 1 | 7.52 |
| CHEMBL378875 | — | — | 1 | 7.30 |
| CHEMBL383409 | — | — | 1 | 7.22 |
| CHEMBL205331 | — | — | 1 | 7.19 |
| CHEMBL383272 | — | — | 1 | 7.05 |
| CHEMBL206207 | — | — | 1 | 6.96 |
| CHEMBL208450 | — | — | 1 | 6.89 |
| CHEMBL377284 | — | — | 1 | 6.80 |
| CHEMBL205938 | — | — | 1 | 6.75 |
| CHEMBL383210 | — | — | 1 | 6.68 |
| CHEMBL207702 | — | — | 1 | 6.54 |
| CHEMBL205308 | — | — | 1 | 6.39 |
| CHEMBL206402 | — | — | 1 | - |
| CHEMBL377797 | — | — | 1 | - |
| CHEMBL383470 | — | — | 1 | - |
| CHEMBL377674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378649 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL380148 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL383064 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL205351 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL380457 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL206359 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL381834 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL378875 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL383409 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL205331 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL383272 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL206207 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL208450 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL377284 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL205938 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL383210 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL207702 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL205308 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL206402 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL377797 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL383470 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL377674 | — | IC50 | > | 500.0 | nM | - |