Assay Detail
Functional
CHEMBL865538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 NL4-3 in MT4 cells
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 7.11 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209452 | — | — | 1 | 7.85 |
| CHEMBL381583 | — | — | 1 | 7.80 |
| CHEMBL168640 | PPL-100 | 1.0 | 1 | 7.80 |
| CHEMBL211715 | — | — | 1 | 7.77 |
| CHEMBL377192 | — | — | 1 | 7.75 |
| CHEMBL380545 | — | — | 1 | 7.72 |
| CHEMBL384210 | — | — | 1 | 7.70 |
| CHEMBL378829 | — | — | 1 | 7.62 |
| CHEMBL378557 | — | — | 1 | 7.60 |
| CHEMBL208724 | — | — | 1 | 7.50 |
| CHEMBL379751 | — | — | 1 | 7.47 |
| CHEMBL261952 | — | — | 1 | 7.41 |
| CHEMBL441528 | — | — | 1 | 7.39 |
| CHEMBL208879 | — | — | 1 | 7.38 |
| CHEMBL209023 | — | — | 1 | 7.36 |
| CHEMBL378194 | — | — | 1 | 7.26 |
| CHEMBL379162 | — | — | 1 | 7.21 |
| CHEMBL384211 | — | — | 1 | 7.19 |
| CHEMBL378134 | — | — | 1 | 7.19 |
| CHEMBL208907 | — | — | 1 | 7.18 |
| CHEMBL205968 | — | — | 1 | 7.17 |
| CHEMBL207077 | — | — | 1 | 7.11 |
| CHEMBL377826 | — | — | 1 | 7.08 |
| CHEMBL438249 | — | — | 1 | 7.06 |
| CHEMBL379540 | — | — | 1 | 7.03 |
| CHEMBL2374438 | — | — | 1 | 6.92 |
| CHEMBL209878 | — | — | 1 | 6.82 |
| CHEMBL378044 | — | — | 1 | 6.71 |
| CHEMBL2374441 | — | — | 1 | 6.70 |
| CHEMBL2374440 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209452 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL381583 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL168640 | PPL-100 | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL211715 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL377192 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL380545 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL384210 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL378829 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL378557 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL208724 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL379751 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL261952 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL441528 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL208879 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL209023 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL378194 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL379162 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL378134 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL384211 | — | EC50 | = | 64.0 | nM | 7.19 |
| CHEMBL208907 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL205968 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL207077 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL377826 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL438249 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL379540 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL2374438 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL209878 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL378044 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL2374441 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2374440 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2374439 | — | EC50 | = | 258.0 | nM | 6.59 |
| CHEMBL208651 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2374444 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL378214 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2374443 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL377238 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2374442 | — | EC50 | - | — | - |