Assay Detail
Functional
CHEMBL865540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 Saquinavir resistant strain SaqR
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.94 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384210 | — | — | 1 | 8.40 |
| CHEMBL211715 | — | — | 1 | 7.85 |
| CHEMBL378557 | — | — | 1 | 7.77 |
| CHEMBL168640 | PPL-100 | 1.0 | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384210 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL211715 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL378557 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL168640 | PPL-100 | EC50 | = | 19.0 | nM | 7.72 |