Assay Detail
Binding
CHEMBL865652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against VEGFR2
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL3337) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Design and structure-activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.40 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205893 | — | — | 1 | 9.00 |
| CHEMBL205108 | — | — | 1 | 8.70 |
| CHEMBL383618 | — | — | 1 | 8.52 |
| CHEMBL204426 | — | — | 1 | 8.40 |
| CHEMBL380702 | — | — | 1 | 8.10 |
| CHEMBL204985 | — | — | 1 | 7.92 |
| CHEMBL204427 | — | — | 1 | 7.89 |
| CHEMBL204727 | — | — | 1 | 7.80 |
| CHEMBL204524 | — | — | 1 | 7.62 |
| CHEMBL383417 | — | — | 1 | 7.60 |
| CHEMBL205405 | — | — | 1 | 7.48 |
| CHEMBL381283 | — | — | 1 | 7.24 |
| CHEMBL205406 | — | — | 1 | 6.96 |
| CHEMBL377345 | — | — | 1 | 6.94 |
| CHEMBL206410 | — | — | 1 | 6.78 |
| CHEMBL205305 | — | — | 1 | 6.29 |
| CHEMBL383299 | — | — | 1 | 6.26 |
| CHEMBL207061 | — | — | 1 | 5.52 |
| CHEMBL383261 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205893 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL205108 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL383618 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL204426 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL380702 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL204985 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL204427 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL204727 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL204524 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL383417 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL205405 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL381283 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL205406 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL377345 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL206410 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL205305 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL383299 | — | IC50 | = | 552.0 | nM | 6.26 |
| CHEMBL207061 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL383261 | — | IC50 | = | 3000.0 | nM | 5.52 |